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While conventional treatments include corticosteroids and cyclophosphamide, they may be inadequate for some patients due to disease progression or relapse, necessitating escalation to rituximab

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The unsupervised clustering of 4453 fibroblasts was used to analyze the senescent cells in keloid and normal skin fibroblast based on senescence-associated marker genes, CDKN2A, TP53, CDKN1A (also known as p21 ) , LMNB1, H2AFX, TP53BP1, SFRP4, CCND1 and GLB1 according as previously reference 20,21

Since, the standards for glutathione assay and the samples are treated with 4-vinylpyridine at same concentrations and same conditions, the marginal negative effect of 4-vinylpyridine is seen in glutathione standards and samples equally and thus treatment with 4-vinylpyridine does not interfere with estimation of glutathione concentration in the samples